简介：

白云峰，男，1981年出生，博士，教授，硕士生导师，美国普渡大学访问学者，山西省教学名师，现任农学与生命科学学院院长、化学生物传感山西省重点实验室副主任。近年来，获得山西省高等学校科学技术奖二等奖1项、山西省科学技术奖二等奖1项、山西省教学成果奖二等奖1项、山西大同大学研究生教育成果特等奖1项，主持省自然科学基金等省级科研项目9项，大同市科研项目2项，参与国家自然科学基金面上项目3项，省自然科学基金等省级项目10余项。主持省级教研项目2项，校级教研项目3项。发表学术论文100余篇，其中被SCI收录60余篇。申请国家发明专利20余项，已获授权国家发明专利16项，实用新型专利8项。

教育背景：

2000.09—2004.06  中国矿业大学生物工程学士

2004.09—2007.06  中国矿业大学生物化工硕士

2010.09—2014.07  山西师范大学分析化学博士

工作简历：

2007.08—2021.03    山西大同大学化学与化工学院助教，讲师，副教授

2017.06—2020.08    山西大同大学化学与化工学院副院长

2018.02—2019.03  美国普渡大学访问学者

2019.12—至今山西大同大学化学生物传感山西省重点实验室副主任

2020.08—2023.8山西大同大学地方产业服务中心主任

2021.03—至今山西大同大学化学与化工学院教授

2023.08—至今山西大同大学农学与生命科学学院院长

代表性论文：

[1] Yunfeng Bai, Feng Feng*, Lu Zhao, Chunyu Wang, Haiyan Wang, MaozhongTian, Jun Qin, Yali Duan, XiaoxiaoHe. Aptamer/thrombin/aptamer-AuNPs sandwich enhanced surface plasmon resonance sensor for the detection of subnanomolarthrombin. Biosensors and Bioelectronics, 2013, 47, 265-270.  SCI一区

[2] Yunfeng Bai, Feng Feng*, Lu Zhao, ZezhongChen, Haiyan Wang, Yali Duan. A turn-on fluorescent aptasensorfor adenosine detection based on split aptamers and graphene oxide. Analyst, 2014, 139(8), 1843-1846.  SCI二区

[3] Yunfeng Bai, Feng Feng*, Lu Zhao, ZezhongChen, Haiyan Wang, Yali Duan. A label-free fluorescent sensor for Hg2+based on target-induced structure-switching of G-quadruplex. Analytical Methods, 2014, 6(3), 662-665.  SCI三区

[4] Yunfeng Bai, Lu Zhao, ZezhongChen, Haiyan Wang, Feng Feng*. A label-free fluorescent sensor for Pb2+based on G-quadruplex and graphene oxide. Analytical Methods, 2014, 6(20), 8120-8123.  SCI三区

[5] Ya Zhang#, Yunfeng Bai#, Feng Feng*, ShaominShuang*. A graphene oxide-based fluorescent aptasensorfor alpha-fetoprotein detection. Analytical Methods, 2016, 8: 6131-6134   SCI三区

[6] Yunfeng Bai, RuifangZhao, Feng Feng*, XiaoxiaoHe. Determination of Lysozyme by Thiol-Terminated Aptamer Based Surface Plasmon Resonance. Analytical Letters, 2017, 50(4): 682-689.  SCI四区

[7] Haiyan Liu, Yunfeng Bai*, Jun Qin, ZezhongChen, Feng Feng*. A novel fluorescent concanavalin A detection platform using anti-concanavalin A aptamer and graphene oxide. Analytical Methods, 2017, 9: 744-747.   SCI三区

[8] Gai-Feng Kang, Yu-Zhen Wang*, Yun-Feng Bai*, Ze-Zhong Chen, Feng Feng*. Surface plasmon resonance based competitive immunoassay for Cd2+. RSC Advances, 2017, 7: 44054-44058.   SCI三区

[9] Haiyan Liu, Yunfeng Bai*, Jun Qin, Haiyan Wang, Yuzhen Wang, ZezhongChen, Feng Feng*.Exonuclease I assisted fluorometric aptasensorfor adenosine detection using 2-AP modified DNA.Sensors and Actuators B: Chemical, 2018, 256: 413-419.   SCI一区

[10] Yanyu Dai, ZhichaoLiu, Yunfeng Bai*, ZezhongChen, Jun Qin, Feng Feng*. A novel highly fluorescent S, N, O co-doped carbon dots for biosensing and bioimaging of copper ions in live cells. RSC Advances, 2018, 8(73): 42246-42252.   SCI三区

[10] Yunfeng Bai, ZhuangzhuangZhang, Lijun Cheng, RuixinWang, XiaoliangChen, Yifan Kong, Feng Feng, Nihal Ahmad, Lang Li, Xiaoqi Liu*. Inhibition of enhancer of zestehomolog 2 (EZH2) overcomes enzalutamide-resistance in castration-resistance prostate cancer. Journal of Biological Chemistry, 2019, 294(25): 9911-9923   SCI二区

[12] XiaoliangChen, Lili Yin, Gan Qiao, Yanhua Li, BaoyuanLi, Yunfeng Bai*, Feng Feng*. Inhibition of Rac1 reverses enzalutamide resistance in castration‑resistant prostate cancer. Oncology Letters, 2020, 20(3): 2997-3005SCI四区

[13] unfeng Bai, Qian Su, JimeiXiao, Feng Feng*, Xiaoming Yang*. Exploration of synthesizing fluorescent silicon nanoparticles and label-free detection of sulfadiazine sodium. Talanta, 2020, 220, 121410   SCI二区

[14] Yunfeng Bai, Jie Liu, Feng Feng*, Xiaoming Yang*. Synthesis of folic acid-mediated copper nanoclusters for the detection of sulfadiazine sodium. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2020, 605, 125376   SCI三区

[15] Yunfeng Bai*, HuilinZhang, Lu Zhao, Yuzhen Wang, XiaoliangChen, Hong Zhai, MaozhongTian, RuiruiZhao, Tao Wang, Hui Xu, Feng Feng*. A novel aptasensorbased on HCR and G-quadruplex DNAzymefor fluorescence detection of Carcinoembryonic Antigen. Talanta, 2021, 221, 121451   SCI二区

[16] RuiruiZhao, Lu Zhao, XiaoliangChen, Haidi Feng, HuilinZhang, Yunfeng Bai*, Feng Feng*, ShaominShuang*. A label-free fluorescence aptasensorbased on HCR and G-quadruplex DNAzymefor the detection of prostate-specific antigen. Analyst, 2021,146(4): 1340-1345   SCI二区

[17] ChenxiaHao, Yunfeng Bai*, ZezhongChen, FanshenGeng, Jun Qin, Tao Zhou, Feng Feng*. Ultralong Room-Temperature Phosphorescence in Aqueous Medium from Silica Confined Polymer Carbon Dots for Multilevel Information Encryption. Dyes and Pigments, 2022, 197, 109890.  SCI二区

[18] ChenxiaHao, Yunfeng Bai*, Lu Zhao, Yayan Bao, Jinai Bian, Hui Xu, Tao Zhou, Feng Feng*. Durable Room-Temperature Phosphorescence of Nitrogen-Doped Carbon Dots-Silica Composites for Fe3+Detection and Anti-counterfeiting.Dyes and Pigments, 2022, 198, 109955  SCI二区

[19] Zhiqiang Bai, Lu Zhao, Haidi Feng, Hui Xu, NianpingZhang, Yanjun Li, Jinping Song, Yunfeng Bai*, RonghuaYang*, Feng Feng*. Fabricating Aptamer-functionalized Ti3C2therapeutic nanoplatform for targeted chemo-photothermal therapy of cancer. Materials & Design, 2023, 226, 111656  SCI一区

[20] Zhiqiang Bai, Lu Zhao, Haidi Feng, Zhihui Xin, ChaoyuWang, ZhixiongLiu, MaozhongTian, Haifei Zhang, Yunfeng Bai*, Feng Feng*. Aptamer modified Ti3C2nanosheets application in smart targeted photothermal therapy for cancer, Cancer Nanotechnology, 2023,14, 35  SCI二区

[21] Haidi Feng,Lu Zhao, Zhiqiang Bai, Zhihui Xin, ChaoyuWang, LizhenLiu, Jinping Song, Haifei Zhang, Yunfeng Bai*, Feng Feng*. Aptamer modified Zr-based porphyrinicnanoscale metal–organic frameworks for active-targeted chemo-photodynamic therapy of tumors. RSC Advances, 2023, 13(6): 11215-11224    SCI三区

[22] XiaoliangChen*, Lili Yin, Hui Xu, Jie Rong, Miao Feng, Di Jiang, Yunfeng Bai*. Knockdown of RhoA Expression Reverts Enzalutamide Resistance via the p38 MAPK Pathway in Castration-resistant Prostate Cancer. Recent Patents on Anti-Cancer Drug Discovery, 2023, 18(1): 92-99  SCI四区

[23] Yuying Chen, Lu Zhao, MeiqingLiu, XiaoliangChen, Lihua Zhang, Hui Xu, ZezhongChen, Aiai Wang, Yuzhen Wang*,Yunfeng Bai*, Feng Feng*. Aptamer-Functionalized Nanoscale Metal–Organic Frameworks for Targeted Photothermal-Chemo Combined Tumor Therapy. ACS Applied Nano Materials,2024, 7(9),10719-10730SCI二区

[24] ChaoyuWang, Zhihui Xin, Zhiqiang Bai, Jiaxin Mao, Yaru Li, ZhifangJia, KeweiWang, Lu Zhao*, Yunfeng Bai*,Feng Feng*. A Covalent Organic Frameworks-based Nanoplatform with Enhanced Photothermal and Photodynamic Performance for Targeted Tumor Therapy. Materials Chemistry Frontiers, 2024, 8(16), 2736-2744SCI二区

[25] MeiqingLiu, Lu Zhao*, Yuying Chen, XiaoliangChen, Jiang Li, ZezhongChen, Hui Xu, Yingying Zhao, Yunfeng Bai*, Feng Feng*. Aptamer-modified Nb2C multifunctional nanomedicine for targeted photothermal/chemotherapy combined therapy of tumor. Molecular Pharmaceutics, 2024, 21(8), 4047−4059SCI二区

[26] Tao Zhou, ChenxiaHao, Yunfeng Bai*, PengliChen, Tao Ma, GuifangHong,Chenguang Yin, Feng Feng*. Multiple immobilized borate composites achieving color-tunable longafterglow in aqueous media for bioimaging and anti-counterfeiting. Microchemical Journal, 2024, 201, 110653SCI二区

[27] RuiruiZhao, Yunfeng Bai*,Yujing Guo*, Feng Feng*, ShaominShuang*. Aptamer-Modified Tetrahedral DNA Nanostructures as Drug Delivery System for Cancer Targeted Therapy.Macromolecular Bioscience, 2024,24(4),2300420.SCI四区

[28] Zhihui Xin, Lu Zhao*, Zhiqiang Bai, ChaoyuWang, ZhixiongLiu, Jun Qin, LizhenLiu, Haifei Zhang, Yunfeng Bai*, Feng Feng*.Aptamer-functionalized hollow carbon nanospheres for targeted chemo-photothermal therapy of breast tumor.Materials Chemistry Frontiers, 2024, 8(24), 4049-4058  SCI二区

[29] Yaru Li*,Lu Zhao,Jiali Wang, Long Ma*, Yunfeng Bai*, Feng Feng*. Argonaute-based nucleic acid detection technology: advantages, current status, challengesand perspectives. ACS Sensors,2024,9(11), 5665–5682SCI一区

[30] Yaru Li*,Lu Zhao,Long Ma*, Yunfeng Bai*, Feng Feng*. CRISPR/Cas and Argonaute-powered lateral flow assay for pathogens detection. Critical Reviews in Food Science and Nutrition, 2024, doi.org/10.1080/10408398.2024.2416473SCI一区

[31]Yaru Li*,Lu Zhao,Yunfeng Bai*, Feng Feng*. Applications of covalent organic frameworks (COFs)-based sensors for foodsafety: Synthetic strategies, characteristicsand current state-of-art. Food Chemistry, 2025, 469, 142495  SCI一区

[32]Yaru Li*,Lu Zhao,Long Ma*, Yunfeng Bai*, Feng Feng*. Argonauteprotein powered biosensing for pathogenic biosafety. International Journal of Biological Macromolecules, 2025, 305, 141321  SCI一区

[33]Lin Yuan, LizhenLiu*, Yunfeng Bai*, Yuzhen Wang, Lu Zhao, Zhi Mi, Jun Qin,Feng Feng*.Ratiometricfluorescent and smartphone-assisted dual-mode sensor for folic acid determination based on N-Nb2C QDs/CQDs. Food Chemistry, 2025, 476, 143464   SCI一区

[34]Yuzhen Wang*,Ningna Shi,XiaoyueKang,QiliangPan,MaozhongTian,Yanfeng Wang, Yunfeng Bai*. Sensitive Competitive Electrochemical Immunosensor for Hg (II) Based on Molybdenum Disulfide/Reduced Graphene Oxide/Gold Nanocomposites. Sensors, 2025, 25(3), 623SCI三区

[35]WenliFeng, Lu Zhao*, ChenxiaHao, Lin Yuan, LizhenLiu, Xiaoming Yang*, Yunfeng Bai*, Feng Feng*.Ultra-stable room temperature phosphorescence CDs-based composite materials for anti-counterfeiting application. SpectrochimicaActa Part A: Molecular and Biomolecular Spectroscopy, 2025, 337, 126106  SCI二区

[36]Zhihui Xin, Lu Zhao*, Jianfeng Li, Zhiqiang Bai, Yunfeng Bai*,Feng Feng*. Multifunctional nanozyme for tumor-targeted photothermal/catalytic combination therapy. Materials Chemistry Frontiers, 2025, 9(11), 1702–1715SCI三区

[37]Jianfeng Li, Zhihui Xin, Zhiqiang Bai, Jiang Li, Lu Zhao*,Yunfeng Bai*, Feng Feng*. A smart nanocomposite based on Mo2C MXenefor active targeted photothermal-chemotherapy of cancer in NIR-II biowindows. ACS Biomaterials Science & Engineering, 2025, 11(6), 3307-3317  SCI三区

[38]Yaru Li*, Lu Zhao, Wen Kang, Long Ma*, Yunfeng Bai*, Feng Feng*. Multiplexed CRISPR/Cas and Argonautedetection technology: strategies, challenges, and perspectives. Trends in Analytical Chemistry, 2025, 191, 118329  SCI一区

[39]Lu Zhao#, Aiai Wang#, Yaru Li, Yunfeng Bai*, Feng Feng*. A smart Zr/Co porphyrin MOFs-based nanotheranostics: Triggering ROS storm for potentiated tumor therapy. Chemical Engineering Journal, 2025, 520, 165992SCI一区，TOP期刊

[40]Zhiqiang Bai, Lu Zhao*, Zhihui Xin, Jiang Li, Yunfeng Bai*, Feng Feng*. Smart therapeutic nanoplatform based on Ti3C2MXenesfor tumor targeted PTT/PDT/CHT at low temperatures. Molecular Pharmaceutics, 2025, 22(8), 4995-5006  SCI二区

[41]Jing Tan, Zhiqiang Bai, Na Wu, LiangliangWang, Yunfeng Bai*. Biopanningand design of RGD-modified phage displayed titanium-binding peptides with biofunctionalityand binding stability. Biosurfaceand Biotribology, 2025, 11, e70010   SCI四区

[42]Hui Xu, Lu Zhao*, XiaoliangChen, Zhiqiang Bai, Yanjun Li, NianpingZhang, Yunfeng Bai*, Feng Feng*. PD-L1 aptamer-functionalized gold nanorods for targeted combined chemo-photothermal therapy in breast cancer. Bioconjugate Chemistry, 2025, 36(8), 1854-1864SCI二区

[43]XiaoaoWang, Lu Zhao, Yunfeng Bai*, Feng Feng*. Studies on Ultralong Lifetime Room Temperature Phosphorescence from Crystals of PhenylpyridinylCarbazoles. Crystal Growth & Design, 2025, 25(22), 9620-9629   SCI二区

[44]HaizhenLv, Zhiqiang Bai, Yanjun Li*, Lu Zhao*, Yunfeng Bai*,Feng Feng*. Enhanced therapeutic efficacy of folic acid-decorated Ti3C2MXenesin targeted combination therapy for liver cancer. Materials Chemistry Frontiers, 2025, 9(22), 3323-3331SCI三区

[45]Yunfeng Bai, Haifei Zhang*. Freeze-enabled synthesis of functional materials: fundamental, progress, and applications. Progress in Materials Science, 2026, 155, 101523  SCI一区，TOP期刊

[46]Lu Zhao#, WenliFeng#, ChenxiaHao, Lin Yuan, Lizhenliu, Xiaoming Yang*, Yunfeng Bai*, Feng Feng*. Activating aqueous room temperature phosphorescence in N, S, B co-doped carbon dots for Fe3+detection and anti-counterfeiting. SpectrochimicaActa Part A: Molecular and Biomolecular Spectroscopy, 2026, 348, 127243  SCI二区

[47]ZhixiongLiu*, Xiaofang Zhao, HaobingYang, Hongbin Yan, Kai Dong, ShuyuWang, Zhen Lu, Yunfeng Bai*, Feng Feng. Transparent hydrophobic organoalkoxysilane-derived inorganic-organichybrids for protecting sandstone. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 734, 139461  SCI二区

[48]Hui Xu; Lu Zhao*; XiaoliangChen; Aiai Wang; Jianfeng Li; Yunfeng Bai*; Feng Feng*.Aptamer-Functionalized AuNRNanoplatform for Active Targeted Chemo-Photothermal Therapy of Tumor.Bioconjugate Chemistry, 2026, 37(2), 384-394  SCI二区

[49]Lu Zhao#,Jianfeng Li#,XuehuiZhang,Yunfeng Bai*,Feng Feng*.Cascade Nanoreactor Based on Mo2C MXenefor NIR-II-Activated Multimodal Therapy of Cancer.Molecular Pharmaceutics, 2026, 23(3), 1955-1968SCI二区

Jing Tan, Na Wu, Zhiqiang Bai,Yunfeng Bai*. Guiding macrophage temporal evolution via integrin targeting on peptide–functionalized titanium surfaces to optimize the host response. Colloids and Surfaces B: Biointerfaces, 2026, 265, 115699  SCI二区

课题研究：

[1]基于空心碳纳米球的复合治疗系统对肿瘤主动靶向治疗的研究（2024054），大同市科技计划项目，2024.12—2026.12

[2]基于PNMOFs的纳米治疗系统对肿瘤多模式靶向治疗的研究（20230036），山西省留学人员科技活动择优资助项目，2023.5—2026.5

[3]基于MXenes和核酸适体的复合纳米治疗系统对肿瘤多模式靶向治疗的研究（202303******324），山西省基础研究计划面上项目，2022.10—2025.10

[4]基于适体功能化COFs的纳米载药系统用于多模式肿瘤治疗研究（2021L368），山西省高等学校科技创新项目，2021.9—2023.8

[5]基于贵金属纳米簇和荧光碳点的肿瘤标志物检测新策略研究（2020-133），山西省省筹资金资助回国留学人员科研项目，2020.7—2023.7

[6]基于功能核酸的光化学生物传感器研究（2020KJ023），山西省高等学校科学研究优秀成果培育项目，2020.6—2023.6

[7]基于核酸适配体的肿瘤早期诊断新方法研究（2019L0735），山西省高科技开发项目，2019.7—2021.6

[8]基于核酸适配体的肿瘤标志物检测新方法研究（201801D121035），山西省基础研究计划（自然科学基金），2018.12—2020.12

[9]基于i-motif DNA和氧化石墨烯的生物传感新技术研究（2014020），化学生物传感与计量学国家重点实验室开放基金项目，2015.3—2017.3

[10]i-motif DNA与氧化石墨烯的相互作用研究及其在生物传感领域中的应用（2015179），山西省高科技开发项目，2015.3—2017.3

[11]基于i-motif DNA和氧化石墨烯的新型生物传感器研究（2015023），大同市工业科技攻关计划项目，2015.10—2017.12

[12]基于功能核酸的新型生物传感器研究（2014-B-03），山西大同大学博士科研启动项目，2015.1—2017.12

获奖：

[1]基于功能核酸的光化学生物传感器研究，山西省高等学校优秀成果奖（科学技术），自然科学奖二等奖，2020.6

[2]基于信号放大技术的光化学生物传感研究，山西省科学技术奖，自然科学奖二等奖，2021.3

[3]新建硕士学位授权单位研究生课程体系建设研究，山西省教学成果奖（高等教育），二等奖，2021.10

国家发明专利：

[1]一种Fe/Mn 卟啉基双金属有机骨架及其制备方法和应用．国家发明专利，申请日期：2025.7.14. 申请号：CN202510967127.9

[2]一种具有双酶活性的复合纳米材料及其制备方法和应用．国家发明专利，申请日期：2025.6.13. 申请号：CN202510793491.8

[3]一种多功能肿瘤靶向低温治疗纳米平台及其应用．国家发明专利，授权日期：2025.11.11，专利号：ZL202510117488.4

[4]一种多功能纳米酶及其制备方法和应用．国家发明专利，申请日期：2024.11.8. 申请号：CN202411592970.5

[5]用于乳腺癌治疗的主动靶向纳米药物及其制备方法和应用．国家发明专利，申请日期：2024.4.26. 申请号：CN2024105148070

[6]一种乳腺癌靶向纳米药物及其制备方法和应用．国家发明专利，申请日期：2024.4.22. 申请号：CN2024104853191

[7]用于乳腺癌联合治疗的靶向纳米药物及其制备方法和应用．国家发明专利，申请日期：2024.4.22. 申请号：CN2024104853223

[8]一种纳米靶向载药复合物及其制备方法和应用．国家发明专利，授权日期：2026.2.13，专利号：ZL202211049693.4

[9]一种二氧化硅/氮掺杂碳纳米复合物及其制备方法与应用．国家发明专利，授权日期：2024.6.7，专利号：ZL202110812737.3

[10]一种磷光二氧化硅/碳纳米复合物及其制备方法和应用．国家发明专利，授权日期：2024.4.9，专利号：ZL202110723231.5

[11]基于杂交链式反应和核酶的荧光适配体传感器及其应用．国家发明专利，申请日期：2020.11.5，申请号：CN202011225724.8

[12]基于杂交链式反应和核酶的传感器及癌胚抗原检测方法．国家发明专利，授权日期：2023.10.27，专利号：ZL202010080734.0

[13]基于杂交链式反应的荧光DNA传感器及E542K基因检测方法．国家发明专利，授权日期：2022.9.9，专利号：ZL202010080730.2

一种N’-（喹啉-2-亚甲基）-7-二乙胺基香豆素-3-甲酰肼及其制备方法和应用．国家发明专利，授权日期：2018.5.4，专利号：ZL201510824122.7

荣誉：

优秀研究生指导教师，优秀教师，优秀教育工作者，优秀共产党员，优秀班主任，科研工作先进个人等。